Across the United States, communities are reckoning with the rising (mis)use of opioids and the resulting increase in substance overdoses. In 2016, opioids were involved in 42,249 deaths. The over prescription and (mis)use of opioids is taking a toll on the country, resulting in death, visits to the emergency room, hospital stays, and unmeasurable pain felt by those who have become addicted to these drugs as well as their families and communities. The opioid epidemic is one of the largest public health issues we face. As a response to this growing crisis, Denver conducted a needs assessment to gather information from people who are directly impacted, and the City brought together a group of leaders from across government agencies and community organizations to address the issue. Together, the Collective Impact Group established a 5-year plan to address opioid (mis)use in Denver.